![]() ![]() Oxybutynin had the highest risk of affect/mood disorder, agitation, and balance/movement disorder however, it had the lowest risk of headache/migraine compared with all OAB medications. Increasing the dose of tolterodine or fesoterodine was not associated with increased NP ADEs. Neuropsychiatric (NP) ADEs were highest with tolterodine and fesoterodine usage (16% and 15.6%, respectively) and transdermal oxybutynin had the lowest (6.5%). The most frequently reported OAB medications were mirabegron (35%), transdermal oxybutynin (27%), and solifenacin (25%). ResultsĪ total number of 14,102 reports were identified. χ 2 values were calculated to assess the association between ADEs and dosage. Disproportionality analysis was used to detect the risk signals for each OAB medication and ADEs. Food and Drug Administration Adverse Event Report System (FAERS) database was queried from 2004 to 2019. Food and Drug Administration Adverse Event Report System database. The aim of the study was to evaluate the association between OAB medications and adverse drug events (ADEs) through the self-reporting U.S. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website ( ImportanceĬlinical data on the use of overactive bladder (OAB) medications are limited by the physician interpretation of adverse effects rather than those that are patient reported. Supplemental digital content is available for this article. did the analysis and interpretation of data, C.S. Per the Food and Drug Administration, it is not required because it is public access data.ī.C., S.D., and C.S. The authors have declared they have no conflicts of interest. This article was published online ahead of print on April 24, 2022.Ĭhristina Sze, MD and Siri Drangsholt, MD contributed equally. ![]() ♭epartment of Surgery, University of Montreal (CHUM), Montreal, Canada.Ĭorrespondence: Bilal Chughtai, MD, Weill Cornell Medicine/New York Presbyterian Hospital, 525 E. ∥Division of Urology, Department of Surgery, University of Toronto, Toronto, Canada §Department of Urology, Albany Medical Center, Albany, NY ‡University of Texas Health, San Antonio, San Antonia, TX †Department of Urology, Westchester Medical Center Health Network, New York, NY From the ∗Weill Cornell Medicine/New York Presbyterian Hospital ![]()
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